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KMID : 0848020040070010007
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Journal of Korean Breast Cancer Society
2004 Volume.7 No. 1 p.7 ~ p.21
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Increase of Fat Necrosis after Radiation Therapy Following Mastectomy and immediate TRAM Flap Reconstruction in High-risk Breast Cancer Patients
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Son, Byung Ho
Lee, Taek Jong/Lee, Sang Wook/Hwang, Ui Kang/Kwak, Beom Seok/Ahn, Sei Hyun
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Abstract
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urpose: This study evaluated the benefit of radiation erapy in high-risk breast cancer patients who have !ceived immediate transverse rectus abdominis myocu.neous (TRAM) flap reconstruction. The evaluation involved ethods: A retrospective review was performed on 102 atients who underwent mastectomy and immediate TRAM 3p reconstruction between 1996 and 2001 at the Asan edical Center (Seoul, Korea). The mean patient age was 1 years, and the median follow-up time was 33 months. esults: Moderate or severe TRAM flap fat necrosis ;cur-red more frequently in patients receiving radiation erapy than those not receiving radiation therapy (55.6%
19.4%, P=0.026). In the group with high-risk patients, two mor recurrences occurred (one-locoregional and one- syamic). Among the 102 patients, thirteen had recurnces, including only two high-risk patients, with almost of em being systemic recurrences except four locoregional currences.
inclusion: Our findings showed that radiation therapy creased flap fat necrosis in high-risk patients underwent mediate TRAM flap reconstruction. Such necrosis can suit in poor outcomes for reconstruction. We recommend
careful consideration prior to using radiation therapy on highrisk breast cancer patients after immediate TRAM flap reconstruction, where clinicians need to balance the possible positive effects on recurrence with the possible negative effects on flap tissue.
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KEYWORD
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